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mant itpγs 2 3 o  (Jena Bioscience)


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    Jena Bioscience mant itpγs 2 3 o
    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). <t>MANT-ITPγS</t> served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.
    Mant Itpγs 2 3 O, supplied by Jena Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mant itpγs 2 3 o/product/Jena Bioscience
    Average 90 stars, based on 4 article reviews
    mant itpγs 2 3 o - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice"

    Article Title: Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0068009

    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.
    Figure Legend Snippet: Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.

    Techniques Used: Concentration Assay, Knock-Out, Activity Assay

    Comparison of concentration response curves of putative of AC5-selective inhibitors on recombinant AC1, 2 and 5. (A) SQ22,536, (B) vidarabine, (C) NKY80. MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with forskolin (100 µM) and GTPγS (10 µM). Data are the means ± S.D. of experiments with three independent membrane preparations of Sf9 -cells expressing AC1, 2 or 5 performed in duplicates.
    Figure Legend Snippet: Comparison of concentration response curves of putative of AC5-selective inhibitors on recombinant AC1, 2 and 5. (A) SQ22,536, (B) vidarabine, (C) NKY80. MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with forskolin (100 µM) and GTPγS (10 µM). Data are the means ± S.D. of experiments with three independent membrane preparations of Sf9 -cells expressing AC1, 2 or 5 performed in duplicates.

    Techniques Used: Concentration Assay, Recombinant, Activity Assay, Expressing

    Inhibitor potencies on mouse heart AC and on AC1, 2 and 5.
    Figure Legend Snippet: Inhibitor potencies on mouse heart AC and on AC1, 2 and 5.

    Techniques Used:



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    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). <t>MANT-ITPγS</t> served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.
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    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). <t>MANT-ITPγS</t> served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.
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    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). <t>MANT-ITPγS</t> served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.
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    Image Search Results


    Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.

    Journal: PLoS ONE

    Article Title: Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

    doi: 10.1371/journal.pone.0068009

    Figure Lengend Snippet: Concentration response curves of SQ22,536 (A) , vidarabine (B) and NKY80 (C) on mouse heart AC from wild type (WT) vs. AC5 knockout mice (AC5KO). MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with FS (100 µM) and GTPγS (10 µM) in the absence of inhibitor. Absolute activites in WT vs. AC5KO hearts (pmol cAMP · mg −1 · min −1 , ± SD): 136.7±46.51 vs. 120.1±31.4; p = 0.64. Data are the means ± S.D. of experiments with cardiac membrane preparations from three WT or AC5KO mice respectively performed in duplicates.

    Article Snippet: MANT-ITPγS (2′(3′)- O -( N -methylanthraniloyl)-inosine 5′-[γ-thio]triphosphate) was obtained from Jena Bioscience (Jena, Germany).

    Techniques: Concentration Assay, Knock-Out, Activity Assay

    Comparison of concentration response curves of putative of AC5-selective inhibitors on recombinant AC1, 2 and 5. (A) SQ22,536, (B) vidarabine, (C) NKY80. MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with forskolin (100 µM) and GTPγS (10 µM). Data are the means ± S.D. of experiments with three independent membrane preparations of Sf9 -cells expressing AC1, 2 or 5 performed in duplicates.

    Journal: PLoS ONE

    Article Title: Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

    doi: 10.1371/journal.pone.0068009

    Figure Lengend Snippet: Comparison of concentration response curves of putative of AC5-selective inhibitors on recombinant AC1, 2 and 5. (A) SQ22,536, (B) vidarabine, (C) NKY80. MANT-ITPγS served as a potent reference AC inhibitor (D). Maximal AC activities represent AC activity under stimulation with forskolin (100 µM) and GTPγS (10 µM). Data are the means ± S.D. of experiments with three independent membrane preparations of Sf9 -cells expressing AC1, 2 or 5 performed in duplicates.

    Article Snippet: MANT-ITPγS (2′(3′)- O -( N -methylanthraniloyl)-inosine 5′-[γ-thio]triphosphate) was obtained from Jena Bioscience (Jena, Germany).

    Techniques: Concentration Assay, Recombinant, Activity Assay, Expressing

    Inhibitor potencies on mouse heart AC and on AC1, 2 and 5.

    Journal: PLoS ONE

    Article Title: Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

    doi: 10.1371/journal.pone.0068009

    Figure Lengend Snippet: Inhibitor potencies on mouse heart AC and on AC1, 2 and 5.

    Article Snippet: MANT-ITPγS (2′(3′)- O -( N -methylanthraniloyl)-inosine 5′-[γ-thio]triphosphate) was obtained from Jena Bioscience (Jena, Germany).

    Techniques: